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"An immensely, unstoppably, ecstatically demented fairy tale."
—Indiewire
"Audaciously gross, wickedly clever, and possibly Demi Moore's finest hour, The Substance is a gasp-inducing feat from writer-director Coralie Fargeat."
—Rotten Tomatoes
"The humanity of Demi Moore’s performance, the greatest of her career, gives Coralie Fargeat’s boldest ideas an emotional backbeat."
—Slant Magazine
A fading celebrity (Demi Moore) decides to use a black market drug, a cell-replicating substance that temporarily creates a younger, better version of herself.