Lotto and Berenson: Crossed Destinies follows the intertwined journeys of Lorenzo Lotto, a forgotten Renaissance master, and Bernard Berenson, the American Jewish art critic who resurrected his legacy. Through the eyes of actor Alessandro Sperduti, the film retraces Lotto's artistic path across Italy, uncovering the painter's personal and professional struggles. At the same time, it explores Berenson's fascination with Lotto’s ability to capture the human soul, creating a profound reflection on art, ambition, and the fear of being forgotten.